In a bowl, gently mix the ground beef with salt, pepper, garlic powder, and onion powder. Do not overmix.
Divide the beef into four equal portions and gently form them into patties, about 3/4 inch thick. Make a slight indentation in the center of each patty with your thumb to prevent them from puffing up during cooking.
Heat a cast-iron skillet over medium-high heat. Add a tablespoon of oil if your skillet is not well-seasoned.
Place the patties in the hot skillet, ensuring not to overcrowd the pan. You may need to cook in batches.
Sear the burgers for 3-4 minutes per side for medium-rare, or longer depending on your desired doneness. Use a spatula to press down gently on the burgers once after placing them in the skillet to encourage browning.
If adding cheese, place a slice on each burger during the last minute of cooking and cover the skillet to melt.
Lightly toast the burger buns in the skillet or a separate toaster.
Assemble your burgers with your favorite toppings and condiments.
Notes
For the juiciest burgers, use an 80/20 ground beef blend.
Avoid overworking the meat when forming patties; this can make them tough.
A cast-iron skillet provides excellent heat retention for a great sear.
Internal temperature for medium-rare is 130-135°F (54-57°C), medium is 140-145°F (60-63°C), and medium-well is 150-155°F (66-68°C).